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KMID : 0043320140370070862
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Archives of Pharmacal Research
2014 Volume.37 No. 7 p.862 ~ p.872
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Synthesis of 6-deoxymollugins and their inhibitory activities on tyrosinase
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Liang Jing Lu
Javed Umair
Lee Seung-Ho
Park Jae-Gyu
Jahng Yurngdong
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Abstract
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A series of 6-deoxymollugins were prepared five steps from benzaldehyde and its derivatives via phenylboronic acid-catalyzed chromenylation as a key step. Their inhibitory activities against tyrosinase from mushroom were evaluated to show that the parent, methyl 2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate (9a) showed best and promising inhibitory activity at IC50 = 18.3 μM.
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KEYWORD
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6-Deoxymollugin, Chromenylation, Tyrosinase, 4-Hydroxynaphthoic acid
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